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Wednesday, April 29, 2020 | History

2 edition of Decorin-induced inhibition of collagen phagocytosis by fibroblasts. found in the catalog.

Decorin-induced inhibition of collagen phagocytosis by fibroblasts.

Vinay M. Bhide

Decorin-induced inhibition of collagen phagocytosis by fibroblasts.

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Published .
Written in English


About the Edition

Decorin (DCN) is a small, leucine-rich, extracellular matrix proteoglycan that binds collagen. We tested the hypothesis that DCN binding to collagen inhibits phagocytosis of collagen fibrils. Experimentally, this was achieved by analyzing the phagocytosis of collagen and DCN/collagen-coated fluorescent beads by Rat-2 and gingival fibroblasts. The binding and internalization of DCN/collagen-coated beads decreased dose-dependently with increasing concentrations of DCN (p<0.001). DCN-mediated inhibition of collagen phagocytosis was attributed to DCN-collagen interactions. A mimetic peptide corresponding to the leucine-rich repeat (LRR) 3 bound to a triple helical peptide containing the alpha2 integrin-binding site of collagen. When collagen beads were co-incubated with this peptide and a mimetic peptide for LRR 4, marked inhibition (∼55%) of collagen phagocytosis was observed. Thus, the DCN-mediated inhibition of collagen phagocytosis can be attributed to a novel collagen binding domain in DCN which acts co-operatively with LRR 4 to mask the alpha2beta1 integrin-binding site on collagen.

The Physical Object
Pagination79 leaves.
Number of Pages79
ID Numbers
Open LibraryOL19216657M
ISBN 100494072229


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Decorin-induced inhibition of collagen phagocytosis by fibroblasts. by Vinay M. Bhide Download PDF EPUB FB2

Decorin is a small, leucine-rich, chondroitin-dermatan sulphate proteoglycan expressed by neurons and astrocytes in the CNS, but also sequestered in the ECM of many tissues (Hocking et al., R.P.

Mecham (ed.), The Extracellular Matrix: an Overview, Biology of Extracellular Matrix, 41 DOI /_2, # Springer-Verlag Berlin Heidelberg 42 J. Xu and D. Mosher. TGF-␤ is best known in cosmetic dermatology for its ability to promote the production of the extracellular matrix, notably the synthesis of procollagen TGF-␤ also serves as a growth factor for fibroblasts, the cells that produce collagen.

This volume, Proteoglycans in Lung Disease, edited by Drs. Garg, P. Roughley, and C. Hales, represents the interest in this field of proteoglycans as it relates to the lung.

It is presented by a cadre .